STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Isoform A: Cytoplasm,Cytoskeleton,Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Cytoplasm,Cytoskeleton,Spindle,Cytoplasm,Cytoskeleton,Spindle pole,Nucleus;Isoform C: Nucleus;

Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

GO:0005737; GO:0005874; GO:0015630; GO:0005815; GO:0005634; GO:0000922; GO:0042802; GO:0046982; GO:0047485; GO:0008270; GO:0007050; GO:0006974; GO:0071157; GO:0031398; GO:0050821; GO:0007265; GO:0070507