Protein Name
Homer protein homolog 3
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
39836
Protein Length
361
Protein Domain
3D Structure
(PDB ID : 2p8v)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cell junction,Synapse,Postsynaptic cell membrane,Postsynaptic density,Cell junction,Synapse;
Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).
Gene Ontology
GO:0045178; GO:0030054; GO:0005737; GO:0005829; GO:0030425; GO:0098978; GO:0043005; GO:0005886; GO:0014069; GO:0045211; GO:0035256; GO:0042802; GO:0008022; GO:0019904; GO:0007216; GO:0070885; GO:0032703; GO:0006605; GO:0098962; GO:2001256