Gene
Synonyms
KIAA1477 MARK
Protein Name
Serine/threonine-protein kinase MARK1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
89003
Protein Length
795
Protein Domain
3D Structure
(PDB ID : 3ose)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein][tau protein]-L-serine + ATP = [tau protein]-O-phospho-L-serine + ADP + H(+)[tau protein]-L-threonine + ATP = [tau protein]-O-phospho-L-threonine + ADP + H(+)
Localization
Cell membrane,Cytoplasm,Cytoskeleton,Cytoplasm,Cell projection,Dendrite;
Function
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Gene Ontology
GO:0005737; GO:0005856; GO:0030425; GO:0015630; GO:0005886; GO:0005524; GO:0000287; GO:0070300; GO:0005546; GO:0001786; GO:0004674; GO:0048156; GO:0050321; GO:0007010; GO:0030010; GO:0051654; GO:0035556; GO:0000226; GO:0001764; GO:0018105; GO:0006468; GO:0050773; GO:0010975; GO:0016055