Protein Name
Protein LANA1
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
131346
Protein Length
1129
Protein Domain
3D Structure
(PDB ID : 2nd0)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Host nucleus;
Function
Multifunctional protein that plays a role in the replication and long-term persistence of the viral episomal genome in dividing cells. Binds to mitotic chromosomes via its N-terminal region and to a 16-bp imperfect palindrome within the origin of replication (oriP) located in the viral terminal repeat (TR) through its C-terminal. Tethers viral episomes to chromosomes during mitosis. Plays a critical role in the shutdown of lytic gene expression during the early stage of infection by interacting with host TRIM28. Plays also a role in the repression of host NF-kappa-B activity upon TNF-alpha stimulation by promoting the proteasomal degradation of host RELA (PubMed:21697472).
Gene Ontology
GO:0042025; GO:0003677; GO:0039644