CaMKinet | Result

Gene

Syngap1

Synonyms

Protein Name

Ras/Rap GTPase-activating protein SynGAP

UniProt ID

Q9QUH6 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

NCBI Gene ID

Molecular Weight

144722

Protein Length

1308

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 3bxj)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Membrane,Cell junction,Synapse;

Function

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.

Gene Ontology

GO:0030054; GO:0098978; GO:0016020; GO:0014069; GO:0099092; GO:0045202; GO:0005096; GO:0019901; GO:0017124; GO:0046580; GO:0048167; GO:0007165