STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Cell membrane,Cytoplasm,Cytoskeleton,Cleavage furrow,Cytoplasm,Cell cortex,Midbody,Cell projection,Lamellipodium;

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Required for the apical junction formation of keratinocyte cell-cell adhesion. Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436).

GO:0043296; GO:0030424; GO:0005938; GO:0032153; GO:0071944; GO:0032154; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0005768; GO:0031234; GO:0098978; GO:0043231; GO:0030027; GO:0016020; GO:0030496; GO:0005739; GO:0005634; GO:0005886; GO:0098794; GO:0032587; GO:0031982; GO:0019003; GO:0005525; GO:0003924; GO:0017022; GO:0019904; GO:0019901; GO:0051022; GO:0030036; GO:0031532; GO:0051017; GO:0007015; GO:0002363; GO:0030521; GO:0001998; GO:0043297; GO:0038027; GO:0043366; GO:0007155; GO:0030154; GO:0034329; GO:0016477; GO:0000902; GO:0007160; GO:1990869; GO:0071345; GO:0071222; GO:0021795; GO:0036089; GO:0007010; GO:0043542; GO:0097498; GO:0045198; GO:0030950; GO:0021861; GO:0046039; GO:0007229; GO:1903673; GO:0090307; GO:0050919; GO:0060548; GO:0090051; GO:0045792; GO:0010812; GO:0043124; GO:0033144; GO:0043524; GO:0045665; GO:0010977; GO:0090324; GO:1903427; GO:0048812; GO:0042476; GO:0043931; GO:0030838; GO:0046638; GO:0030307; GO:0043280; GO:0032467; GO:0043123; GO:1904996; GO:0060193; GO:0043525; GO:0045666; GO:1901224; GO:0071803; GO:0071902; GO:0045987; GO:0051496; GO:2000406; GO:0045727; GO:1904695; GO:0032956; GO:0051924; GO:0030334; GO:0008360; GO:0050773; GO:0070507; GO:1905274; GO:1905244; GO:2000177; GO:0010975; GO:0033688; GO:0003100; GO:0006357; GO:0043200; GO:0042493; GO:0045471; GO:0051384; GO:0009749; GO:0001666; GO:0009612; GO:0007266; GO:0035385; GO:1902766; GO:0007519; GO:0043149; GO:0031098; GO:0061383; GO:0044319