Protein Name
Low-density lipoprotein receptor-related protein 4
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
211880
Protein Length
1905
Protein Domain
3D Structure
(PDB ID : 3v64)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane;
Function
Mediates SOST-dependent inhibition of bone formation (By similarity). Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling (By similarity). Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. Plays an essential role in the process of digit differentiation.
Gene Ontology
GO:0009986; GO:0030425; GO:0016021; GO:0031594; GO:0043025; GO:0005886; GO:0044853; GO:0014069; GO:0097060; GO:0034185; GO:0005509; GO:0042803; GO:0030971; GO:0097110; GO:0150094; GO:0030509; GO:0048813; GO:0009953; GO:0042733; GO:0006897; GO:0001942; GO:0001822; GO:0050771; GO:0090090; GO:0030279; GO:0042475; GO:0050731; GO:1901631; GO:1904395; GO:0097104; GO:0097105; GO:0051290; GO:0009954; GO:0071340; GO:0050808; GO:0051124; GO:0016055