CaMKinet | Result

Gene

PI4KB

Synonyms

PIK4CB

Protein Name

Phosphatidylinositol 4-kinase beta

UniProt ID

Q9UBF8 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000357866

NCBI Gene ID

5298

Molecular Weight

91379

Protein Length

816

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2n73)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.1.67; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)

Localization

Endomembrane system,Mitochondrion outer membrane,Rough endoplasmic reticulum membrane,Golgi apparatus,Golgi apparatus membrane,Cytoplasm,Perinuclear region;

Function

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).

Gene Ontology

GO:0005737; GO:0005829; GO:0005768; GO:0000139; GO:0016020; GO:0005741; GO:0048471; GO:0030867; GO:0004430; GO:0071889; GO:0005524; GO:0006661; GO:0046854; GO:0048015; GO:0006898; GO:0007165