PPARGC1A | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
PPARGC1A
Synonyms
LEM6 PGC1 PGC1A PPARGC1
Protein Name
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
UniProt ID
Q9UBK2-3 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000264867
NCBI Gene ID
10891
Molecular Weight
91027
Protein Length
798
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1xb7)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Isoform 1: Nucleus,Nucleus,PML body;Isoform B4: Nucleus;Isoform B4-8a: Cytoplasm,Nucleus;Isoform B5: Nucleus,Nucleus,PML body;Isoform 9: Nucleus;
Function
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.
Gene Ontology
GO:0097440; GO:0022626; GO:1990844; GO:0043231; GO:0043025; GO:0005719; GO:0005654; GO:0005634; GO:0016605; GO:1990843; GO:0043014; GO:0050681; GO:0031490; GO:0003677; GO:0030331; GO:0016922; GO:0030374; GO:0042975; GO:1990841; GO:0003723; GO:0043565; GO:0003713; GO:0003712; GO:0008134; GO:0031625; GO:1990845; GO:0060612; GO:0007568; GO:0008209; GO:0030521; GO:0000422; GO:0050873; GO:0001678; GO:0045333; GO:0071313; GO:0071392; GO:0071372; GO:0071332; GO:0071333; GO:0071456; GO:0071354; GO:1904637; GO:0071222; GO:0071250; GO:0034599; GO:0035865; GO:1904639; GO:0097067; GO:0071560; GO:0071356; GO:0021549; GO:0032922; GO:0007623; GO:0007586; GO:0097009; GO:0019395; GO:0051552; GO:0030900; GO:0006012; GO:0006094; GO:0007005; GO:0006397; GO:0045820; GO:0090258; GO:0043524; GO:1901215; GO:0001933; GO:2000272; GO:0014912; GO:0048662; GO:2001171; GO:1901857; GO:0120162; GO:0051091; GO:0046321; GO:0010628; GO:1904635; GO:0045722; GO:0035066; GO:1901860; GO:0010822; GO:1901863; GO:2000184; GO:0048661; GO:0045944; GO:0045893; GO:0050821; GO:0065003; GO:0042752; GO:2000310; GO:0006355; GO:0022904; GO:0009409; GO:0002021; GO:0014878; GO:0071871; GO:0002931; GO:0043201; GO:1901558; GO:1904640; GO:0014850; GO:0071873; GO:0000302; GO:0042594; GO:0008380; GO:0014732; GO:0001659; GO:0006367
 
Gene Ontology