Protein Name
ERBB receptor feedback inhibitor 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
50560
Protein Length
462
Protein Domain
3D Structure
(PDB ID : 2rf9)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cell membrane,Nucleus;
Function
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).
Gene Ontology
GO:0005737; GO:0005829; GO:0031234; GO:0005634; GO:0005096; GO:0019901; GO:0017124; GO:0031267; GO:0071474; GO:0071549; GO:0071364; GO:0032869; GO:0036120; GO:0048286; GO:0060428; GO:0060426; GO:1903243; GO:0032966; GO:0042059; GO:0007175; GO:0070373; GO:0032691; GO:0031953; GO:0042536; GO:0045616; GO:0061469; GO:0043589