Protein Name
Serine/threonine-protein kinase tousled-like 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
86700
Protein Length
766
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Function
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
Gene Ontology
GO:0005634; GO:0005524; GO:0004674; GO:0007049; GO:0006974; GO:0006325; GO:0006886; GO:0035556; GO:0006468; GO:0001672