Gene
Synonyms
HDAC7 HDAC7B HDRP KIAA0744 MITR
Protein Name
Histone deacetylase 9
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
111297
Protein Length
1011
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
Gene Ontology
GO:0005737; GO:0000118; GO:0035097; GO:0005654; GO:0005634; GO:0005667; GO:0004407; GO:0034739; GO:0042826; GO:0046872; GO:0032041; GO:0033558; GO:0005080; GO:0070491; GO:0003714; GO:0008134; GO:0042113; GO:0030183; GO:0032869; GO:0042632; GO:0007507; GO:0016575; GO:0070932; GO:0070933; GO:1990678; GO:0006954; GO:0050710; GO:0051005; GO:0000122; GO:0045892; GO:0030182; GO:0034983; GO:0090050; GO:0048742; GO:0051153; GO:0001975