STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Membrane,Late endosome;

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

GO:0005829; GO:0016021; GO:0005770; GO:0016020; GO:0032991; GO:0030165; GO:0019887; GO:0000186; GO:1990090; GO:0048813; GO:0001701; GO:0038180; GO:0010976