STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Cytoplasm,Cytoskeleton,Microtubule organizing center,Centrosome,Centriolar satellite,Cytoplasm,Cytoskeleton,Cilium basal body,Cytoplasmic vesicle,Secretory vesicle,Acrosome;

Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).

GO:0001669; GO:0034451; GO:0005813; GO:0035869; GO:0005829; GO:0045171; GO:0043231; GO:0015630; GO:0005815; GO:0042803; GO:0044877; GO:0030154; GO:0097711; GO:0060271; GO:0000086; GO:0035735; GO:0007275; GO:0008284; GO:0090316; GO:0071539; GO:0010824; GO:0010389; GO:0007283