STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysine(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysine(36)-[histone H3] + 2 succinate

Nucleus,Nucleus,Nucleolus;

Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3.

GO:0031965; GO:0005730; GO:0005654; GO:0005634; GO:0016706; GO:0003682; GO:0032452; GO:0071558; GO:0051864; GO:0032454; GO:0035575; GO:0005506; GO:0035064; GO:0008270; GO:0007420; GO:0000082; GO:0071557; GO:0070544; GO:0033169; GO:0035574; GO:0061188; GO:0045943; GO:0045893