Gene
Synonyms
CDC2L2 CDC2L3 PITSLREB
Protein Name
Cyclin-dependent kinase 11A
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
91362
Protein Length
783
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Nucleus;
Function
Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
Gene Ontology
GO:0005737; GO:0005634; GO:0005524; GO:0004693; GO:0004672; GO:0004674; GO:0006915; GO:0000278; GO:0006468; GO:0001558; GO:0050684; GO:0006355