Protein Name
Brain-specific angiogenesis inhibitor 1-associated protein 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
60868
Protein Length
552
Protein Domain
3D Structure
(PDB ID : 1wdz)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Membrane,Cell projection,Filopodium,Cell projection,Ruffle,Cytoplasm,Cytoskeleton;
Function
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
Gene Ontology
GO:0015629; GO:0005913; GO:0005737; GO:0005829; GO:0070062; GO:0030175; GO:0005654; GO:0005886; GO:0001726; GO:0098641; GO:0008093; GO:0042802; GO:0070064; GO:0008022; GO:0051764; GO:0051017; GO:0007409; GO:0038096; GO:0008286; GO:0007009; GO:2000251; GO:0030838; GO:0032956; GO:0008360; GO:0009617; GO:0048010