Protein Name
Histone deacetylase 5
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
121978
Protein Length
1122
Protein Domain
3D Structure
(PDB ID : 5uwi)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Localization
Nucleus,Cytoplasm;
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Gene Ontology
GO:0005737; GO:0005829; GO:0005794; GO:0000118; GO:0016607; GO:0005654; GO:0005634; GO:0003682; GO:0004407; GO:0042826; GO:0046872; GO:0032041; GO:0033558; GO:0005080; GO:0070491; GO:0000978; GO:0001085; GO:0008134; GO:0042113; GO:0030183; GO:0032869; GO:0071222; GO:0006325; GO:0006338; GO:0006342; GO:0016575; GO:0006954; GO:0090051; GO:0010832; GO:0000122; GO:0045892; GO:0030182; GO:0051091; GO:0045944; GO:0006476; GO:0040029; GO:0010830; GO:0043393; GO:0014823; GO:0042220