STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Endoplasmic reticulum membrane,Golgi apparatus membrane,Cytoplasmic vesicle,COPII-coated vesicle membrane;Processed sterol regulatory element-binding protein 1: Nucleus;

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters.

GO:0005737; GO:0005783; GO:0005789; GO:0012507; GO:0000139; GO:0016021; GO:0043231; GO:0016020; GO:0005654; GO:0005634; GO:0032991; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0008047; GO:0004879; GO:0046983; GO:0019901; GO:0044877; GO:0000978; GO:0000977; GO:0043565; GO:0032810; GO:0044212; GO:0007568; GO:0071398; GO:0009267; GO:0008203; GO:0007623; GO:0045444; GO:0008286; GO:0008610; GO:0030324; GO:0043170; GO:0042789; GO:0046676; GO:0000122; GO:0045542; GO:0045723; GO:0031065; GO:1902895; GO:0045944; GO:0045893; GO:0010867; GO:1903146; GO:0019217; GO:0003062; GO:0050796; GO:0031647; GO:1903214; GO:0006355; GO:0051591; GO:0032094; GO:0033762; GO:0009749; GO:0032570; GO:0032526