Gene
Synonyms
Fkhr2 Foxo3a
Protein Name
Forkhead box protein O3
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
71064
Protein Length
672
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cytosol,Nucleus,Mitochondrion matrix,Mitochondrion outer membrane;
Function
Transcriptional activator (PubMed:23805378). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (By similarity). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (By similarity). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (By similarity). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301).
Gene Ontology
GO:0005737; GO:0005829; GO:0016020; GO:0005759; GO:0005741; GO:0005739; GO:0005654; GO:0005634; GO:0032991; GO:0008013; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0034246; GO:0019901; GO:0000978; GO:0043565; GO:0001221; GO:0008134; GO:0007568; GO:0001547; GO:0048854; GO:1904646; GO:0071386; GO:0071333; GO:0071456; GO:1990090; GO:0034599; GO:0030330; GO:0097192; GO:0042593; GO:0001544; GO:0008286; GO:0006390; GO:0090090; GO:0030336; GO:0045665; GO:0000122; GO:0097150; GO:0001556; GO:0001542; GO:0043065; GO:2000353; GO:0045648; GO:1901300; GO:0043525; GO:1903428; GO:0045944; GO:0045893; GO:2000177; GO:2000377; GO:0006357; GO:0006355; GO:0006417; GO:0071548; GO:0031667; GO:1990785; GO:0033209