Protein Name
Mitogen-activated protein kinase 7
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
87733
Protein Length
806
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Nucleus,Nucleus,PML body;Isoform 1: Cytoplasm,Nucleus;Isoform 2: Nucleus;Isoform 3: Nucleus;
Function
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity).
Gene Ontology
GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0016605; GO:0005524; GO:0004707; GO:0051019; GO:0004672; GO:0004674; GO:0007049; GO:0030154; GO:0071363; GO:0070301; GO:0071499; GO:0071310; GO:0071560; GO:0035556; GO:0043066; GO:0070885; GO:2000352; GO:0070377; GO:2001240; GO:0034115; GO:0043407; GO:1902176; GO:0060761; GO:0018105; GO:0051247; GO:0045944; GO:0036003; GO:0006468; GO:0045765; GO:0010468