TRPC6 | Short transient receptor potential channel 6
 
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Sequence Viewer
Gene
TRPC6
Synonyms
TRP6
Protein Name
Short transient receptor potential channel 6
UniProt ID
Q9Y210 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000340913
NCBI Gene ID
7225
Molecular Weight
106326
Protein Length
931
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 5yx9)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cell membrane;
Function
Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.
Gene Ontology
GO:0034703; GO:0005737; GO:0005887; GO:0016020; GO:0005886; GO:0036057; GO:0003779; GO:0042805; GO:0051117; GO:0005262; GO:0005261; GO:0030276; GO:0070679; GO:0042803; GO:0015279; GO:0007568; GO:0070588; GO:0006812; GO:0070301; GO:0071456; GO:0006828; GO:0050774; GO:0030182; GO:0030168; GO:0051928; GO:0007204; GO:0032414; GO:0045666; GO:0010800; GO:0051480; GO:0007338
 
Gene Ontology