Protein Name
Cofilin-2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
18737
Protein Length
166
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Nucleus matrix,Cytoplasm,Cytoskeleton;
Function
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).
Gene Ontology
GO:0015629; GO:0070062; GO:0005615; GO:0031674; GO:0016363; GO:0030018; GO:0051015; GO:0030042; GO:0030043; GO:0046716; GO:0030836; GO:0045214; GO:0007519