GIT1 | ARF GTPase-activating protein GIT1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer
Gene
GIT1
Synonyms
-
Protein Name
ARF GTPase-activating protein GIT1
UniProt ID
Q9Y2X7 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000225394
NCBI Gene ID
28964
Molecular Weight
84341
Protein Length
761
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm;
Function
GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13 (By similarity).
Gene Ontology
GO:0044305; GO:0005829; GO:0005925; GO:0016020; GO:0005096; GO:0046872; GO:0044877; GO:0048013; GO:0099171; GO:0032465; GO:0008277; GO:2000300
 
Gene Ontology