DAGLA | Sn1-specific diacylglycerol lipase alpha
 
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Sequence Viewer
Gene
DAGLA
Synonyms
C11orf11 KIAA0659 NSDDR
Protein Name
Sn1-specific diacylglycerol lipase alpha
UniProt ID
Q9Y4D2 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000257215
NCBI Gene ID
747
Molecular Weight
114952
Protein Length
1042
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
3.1.1.-; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cell membrane;
Function
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Gene Ontology
GO:0099055; GO:0005886; GO:0045211; GO:0043196; GO:0047372; GO:0046872; GO:0019369; GO:0046340; GO:0071926; GO:0007216; GO:0007405; GO:0022008; GO:0042136; GO:0098921