Protein Name
Protein phosphatase methylesterase 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
42315
Protein Length
386
Protein Domain
3D Structure
(PDB ID : 3c5v)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol
Function
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.
Gene Ontology
GO:0005654; GO:0045296; GO:0051722; GO:0019901; GO:0051721; GO:0019903; GO:0004864; GO:0019888; GO:0000086; GO:0006482