Protein Name
Nuclear receptor corepressor 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
273657
Protein Length
2514
Protein Domain
3D Structure
(PDB ID : 1kkq)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).
Gene Ontology
GO:0000118; GO:0016020; GO:0016604; GO:0000790; GO:0016363; GO:0005654; GO:0005634; GO:0017053; GO:0003682; GO:0000981; GO:0042826; GO:0005112; GO:0035257; GO:0047485; GO:0001012; GO:0043565; GO:0003714; GO:0060766; GO:1903799; GO:0000122; GO:0045892; GO:0072365; GO:0019216