CABIN1 | Calcineurin-binding protein cabin-1
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
CABIN1
Synonyms
KIAA0330
Protein Name
Calcineurin-binding protein cabin-1
UniProt ID
Q9Y6J0 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000263119
NCBI Gene ID
23523
Molecular Weight
246352
Protein Length
2220
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1n6j)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.
Gene Ontology
GO:0016235; GO:0005829; GO:0005654; GO:0005634; GO:0004864; GO:0007166; GO:0006336