STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Cytoplasm,Cell projection,Cell junction,Synapse,Synaptosome,Cell projection,Ruffle membrane,Membrane,Cytoplasmic vesicle membrane,Cell junction,Synapse,Cytoplasm,Cytosol,Cell membrane;

Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission.

GO:0043679; GO:0030054; GO:0005737; GO:0030659; GO:0005856; GO:0005829; GO:0098978; GO:0048471; GO:0005886; GO:0098839; GO:0032587; GO:0045202; GO:0043195; GO:0008092; GO:0005543; GO:0007015; GO:0007010; GO:0048812; GO:0097320; GO:1900006; GO:0072657; GO:0072659; GO:0099149; GO:0048488