Gene
Synonyms
Kiaa0981 Pip5k3
Protein Name
1-phosphatidylinositol 3-phosphate 5-kinase
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
236877
Protein Length
2097
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)
Localization
Cytoplasmic vesicle membrane,Endosome membrane;
Function
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole.
Gene Ontology
GO:0005911; GO:0031410; GO:0030659; GO:0005829; GO:0031901; GO:0010008; GO:0000139; GO:0031902; GO:0045121; GO:0048471; GO:0012506; GO:0000285; GO:0016308; GO:0052810; GO:0005524; GO:0008270; GO:0035556; GO:0032288; GO:0034504; GO:2000785; GO:0042147