Protein Name
Cadherin-2
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
99686
Protein Length
906
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane,Cell junction,Cell surface;
Function
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Gene Ontology
GO:0045177; GO:0016342; GO:0009986; GO:0005913; GO:0005737; GO:0005916; GO:0098978; GO:0005887; GO:0099060; GO:0099059; GO:0014704; GO:0030027; GO:0016020; GO:0043005; GO:0005886; GO:0014069; GO:0032991; GO:0045202; GO:0030315; GO:0008013; GO:0045296; GO:0005509; GO:0008092; GO:0050998; GO:0042803; GO:0019901; GO:0044877; GO:0034332; GO:0048514; GO:0016339; GO:0000902; GO:0098609; GO:0044331; GO:0007043; GO:0010001; GO:0007156; GO:0050804; GO:0097150; GO:0051291; GO:0050770; GO:0031641; GO:0032880; GO:0035023; GO:0051966; GO:0007416; GO:0099560