Protein Name
Astrocytic phosphoprotein PEA-15
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
15040
Protein Length
130
Protein Domain
3D Structure
(PDB ID : 1n3k)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm.
Gene Ontology
GO:0005829; GO:0005634; GO:0006915; GO:0008643; GO:0000077; GO:1902042; GO:0046325; GO:1902043