Help Instruction
- Double clicking on the substrate will redirect to the uniprot entry.
- Clicking in the block having the substrate will zoom into its phophosites
- Clicking the center of the circle will lead to zooming out.
- Clicking on the phosphosite will render the phosphosite in its 3D structure (if structure information/mapping is available).
- The color of every substrate has ben kept different in the Sunburst diagram for visual clarity.
- Clicking in the top right corner on the camara icon will download the image.
| Gene Name | Organism | P-Site | Sequence(+/-7) | Conservation | Disorder | Curator Assessment | Reliability | Evidence Class | Evidence Logic | PubMed | Phospho-ELM | PhosphoSite-Plus |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAPKAPK2 (P22893) | Homo sapiens | S316 | LPIFNRISVSE____ | - | 0.4766 | TP | certain | experimental | 73 | 214 | 72 | | 14688255 | Non high throughput (14688255) | - |
| MAPKAPK2* (P22893) | Homo sapiens | S80 | PRPGPELSPSPTSPT | - | 0.8853 | U | likely | experimental | 72 | 214 | | 14688255 | Non high throughput (14688255) | - |
| MAPKAPK2* (P22893) | Homo sapiens | S82 | PGPELSPSPTSPTAT | - | 0.9126 | U | likely | experimental | 72 | 214 | | 14688255 | Non high throughput (14688255) | - |
| MAPKAPK2* (P22893) | Homo sapiens | S85 | ELSPSPTSPTATPTT | - | 0.9081 | U | likely | experimental | 72 | 214 | | 14688255 | Non high throughput (14688255) | - |
| MAPKAPK2* (P22893) | Homo sapiens | T250 | PSCRRSTTPSTIWGP | - | 0.374 | U | likely | experimental | 73 | 214 | 72 | | 14688255 | Non high throughput (14688255) | - |
| MAPKAPK2 (P22893) | Homo sapiens | S52 | RLTGRSTSLVEGRSC | - | 0.3392 | TP | certain | experimental | 72 | 73 | 45 | 9 | | 14688255 | - | - |
| MAPKAPK2 (P22893) | Homo sapiens | S178 | HVLRQSISFSGLPSG | - | 0.6375 | TP | certain | experimental | 72 | 73 | 45 | 9 | | 14688255 | - | - |
Help Instructions
- Hovering on the "*" in "Kinase Gene Name" column will display the text if there is a note by the annotator for the given site.
- The column having "Sequence" motif represents phosphosite and its neighbouring 7 residues (upstream and downstream).
- The score in "Conservation" column varies from 0 to 1; Higher the score more conserved is the site.
- The score in "Disorder" column varies from 0 to 1; Score higher than 0.4 suggests disorder.
- In the "Curator Assessment" column, TP refers to True Positive; FP refers to False Positive; and U refers to unknown if the annoatator cannot decide the status based on available information.
- Hovering on the number in the "Evidence Logic" column will show the name of method used to characterize/infer the phosphosite (for more details plase follow the link)