CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

Sik2

Synonyms

Snf1lk2

Protein Name

Serine/threonine-protein kinase SIK2

UniProt ID

Q8CFH6

Ensembl Gene ID

10090.ENSMUSP00000038761

NCBI Gene ID

235344

Molecular Weight

1,04,198

Protein Length

931

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : N/A)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm

Function

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Gene Ontology

GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0008286; GO:0031588; GO:0032007; GO:0035556; GO:0042149; GO:0046626; GO:0046777

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
IRS1 * (P35568)	Homo sapiens	S794	QHLRLSTSSGRLLYA	0.309	0.5951	TP	certain	experimental	72 \| 73 \| 8 \| 55 \|	12624099	-	-
Irs1 (P35570)	Rattus norvegicus	S789	QHLRLSSSSGRLRYT	-	0.7289	TP	certain	experimental	72 \| 73 \| 8 \| 55 \|	12624099	-	-
Ep300 (B2RWS6)	Mus musculus	S89	SELLRSGSSPNLNMG	-	0.6806	TP	certain	experimental	72 \| 73 \| 55 \| 23 \| 148 \| 8 \|	21084751	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found