| Gene |
Irs1
|
| Protein Name |
IRS1_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Insulin receptor substrate 1 (IRS-1) (pp185) |
| Protein Family |
N/A |
| NCBI Gene ID |
25467
|
| UniProt ID |
P35570
|
| Enzyme Class |
- |
| Molecular Weight |
131178 |
| Protein Length |
1235 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
N/A |
| Function (UniProt annotation) |
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. |
| Gene Ontology |
GO:0005068; GO:0005080; GO:0005158; GO:0005159; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005899; GO:0007568; GO:0008286; GO:0014823; GO:0019901; GO:0019904; GO:0031000; GO:0042169; GO:0042327; GO:0043231; GO:0043434; GO:0043548; GO:0043552; GO:0046627; GO:0046628; GO:0046676; GO:0048009; GO:0051291; GO:0070094; GO:0071478; GO:0090275; GO:1904385; GO:1990416 |
