CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	IRS1
Protein Name	IRS1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Insulin receptor substrate 1 (IRS-1)
Protein Family	N/A
NCBI Gene ID	3667
UniProt ID	P35568
Enzyme Class	-
Molecular Weight	131591
Protein Length	1242
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	N/A
Function (UniProt annotation)	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Gene Ontology	GO:0000165; GO:0001784; GO:0005068; GO:0005070; GO:0005080; GO:0005088; GO:0005158; GO:0005159; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005899; GO:0005901; GO:0007165; GO:0008284; GO:0008286; GO:0010907; GO:0014065; GO:0016303; GO:0032000; GO:0032868; GO:0032869; GO:0038111; GO:0042169; GO:0042593; GO:0043231; GO:0043434; GO:0043548; GO:0043552; GO:0045725; GO:0046326; GO:0046627; GO:0046628; GO:0046676; GO:0046934; GO:0048009; GO:0048015; GO:0051897

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Sik2* (Q8CFH6)	Mus musculus	S794	QHLRLSTSSGRLLYA	0.309	0.5951	TP	certain	experimental	72 \| 73 \| 8 \| 55 \|	12624099	-	-
SIK1 (P57059)	Homo sapiens	S794	QHLRLSTSSGRLLYA	0.309	0.5951	-	-	-	-	12624099	Non high throughput (12624099)	-
RPS6KA1 (Q15418)	Homo sapiens	S1101	GCRRRHSSETFSSTP	0.923	0.8162	-	-	-	-	17709744	Non high throughput (17709744)	-
PIM2 (Q9P1W9)	Homo sapiens	S1101	GCRRRHSSETFSSTP	0.923	0.8162	-	-	-	-	-	-	in-vivo
PIM3 (Q86V86)	Homo sapiens	S1101	GCRRRHSSETFSSTP	0.923	0.8162	-	-	-	-	-	-	in-vivo
PIM1 (P11309)	Homo sapiens	S1101	GCRRRHSSETFSSTP	0.923	0.8162	-	-	-	-	-	-	in-vitro and in-vivo
SIK2 (Q9H0K1)	Homo sapiens	S794	QHLRLSTSSGRLLYA	0.309	0.5951	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04722	Neurotrophin signaling pathway
hsa04910	Insulin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa04930	Type II diabetes mellitus
hsa04960	Aldosterone-regulated sodium reabsorption

NCI Nature PID Pathways

Pathway ID	Pathway Name
avb3_integrin_pathway	Integrins in angiogenesis
igf1_pathway	IGF1 pathway
il2_1pathway	IL2-mediated signaling events
il4_2pathway	IL4-mediated signaling events
insulin_pathway	Insulin Pathway
mtor_4pathway	mTOR signaling pathway
ptp1bpathway	Signaling events mediated by PTP1B
ret_pathway	Signaling events regulated by Ret tyrosine kinase
s1p_s1p2_pathway	S1P2 pathway