CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	DAPK3
Protein Name	DAPK3_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase)
Protein Family	Protein kinase superfamily
NCBI Gene ID	1613
UniProt ID	O43293
Enzyme Class	2.7.11.1
Molecular Weight	52536
Protein Length	454
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Nucleus
Function (UniProt annotation)	Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor.
Gene Ontology	GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005884; GO:0006325; GO:0006355; GO:0006468; GO:0006915; GO:0006940; GO:0007088; GO:0007346; GO:0008022; GO:0008140; GO:0008360; GO:0010506; GO:0016605; GO:0017048; GO:0017148; GO:0030182; GO:0030335; GO:0035556; GO:0042802; GO:0042803; GO:0042981; GO:0043065; GO:0043519; GO:0043522; GO:0045121; GO:0046777; GO:0051893; GO:0071346; GO:0090263; GO:0097190; GO:2000145; GO:2000249; GO:2001241

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
DAPK1 (P53355)	Homo sapiens	S309	LKEYTIKSHSSLPPN	0.436	0.5419	TP	certain	-	72 \| 73 \| 9 \|	15367680	-	-
DAPK1 (P53355)	Homo sapiens	S312	YTIKSHSSLPPNNSY	0.916	0.4186	TP	certain	-	72 \| 73 \| 9 \|	15367680	-	-
DAPK1 (P53355)	Homo sapiens	S318	SSLPPNNSYADFERF	0.015	0.4725	TP	certain	-	72 \| 73 \| 9 \|	15367680	-	-
DAPK1 (P53355)	Homo sapiens	S326	YADFERFSKVLEEAA	0.671	0.3321	TP	certain	-	72 \| 73 \| 9 \|	15367680	-	-
DAPK1 (P53355)	Homo sapiens	S311	EYTIKSHSSLPPNNS	0.624	0.5098	TP	certain	-	73 \| 8 \|	15367680	-	-
DAPK1 (P53355)	Homo sapiens	T265	KDPKRRMTIAQSLEH	0.897	0.1969	TP	certain	-	72 \| 73 \| 273 \| 135 \| 8 \|	15611134	-	-
DAPK1 (P53355)	Homo sapiens	T299	PERRRLKTTRLKEYT	0.621	0.4864	TP	certain	-	72 \| 73 \| 273 \| 135 \| 8 \| 11 \| 9 \|	15611134, 15367680	-	-
DAPK1 (P53355)	Homo sapiens	T306	TTRLKEYTIKSHSSL	0.57	0.5017	TP	certain	-	72 \| 73 \| 273 \| 135 \| 8 \|	15611134	-	-
DAPK3 (O43293)	Homo sapiens	S311	EYTIKSHSSLPPNNS	0.624	0.5098	-	-	-	-	15611134	Non high throughput (15611134)	In vitro
DAPK3 (O43293)	Homo sapiens	T180	EFKNIFGTPEFVAPE	0.874	0.1791	-	-	-	-	15611134	Non high throughput (15611134)	In vitro
DAPK3 (O43293)	Homo sapiens	T225	LGETKQETLTNISAV	0.862	0.3566	-	-	-	-	15611134	Non high throughput (15611134)	In vitro
DAPK3 (O43293)	Homo sapiens	T265	KDPKRRMTIAQSLEH	0.897	0.1969	-	-	-	-	15611134	Non high throughput (15611134)	In vitro
DAPK3 (O43293)	Homo sapiens	T299	PERRRLKTTRLKEYT	0.621	0.4864	-	-	-	-	15611134	Non high throughput (15611134)	In vitro
DAPK3 (O43293)	Homo sapiens	T306	TTRLKEYTIKSHSSL	0.57	0.5017	-	-	-	-	15611134	Non high throughput (15611134)	In vitro
DAPK3 (O43293)	Homo sapiens	S50	FIKKRRLSSSRRGVS	0.058	0.3631	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa05200	Pathways in cancer
hsa05219	Bladder cancer

No NCI Nature pathways found