CaM Kinases known in this pathway:
| Name | Synonyms | EntryName | Phosphorylate Substrates |
|---|---|---|---|
| DAPK1 | Death-associated protein kinase 1 | P53355 | TP53 | Dapk1 | DAPK3 | DDX58 | TPM1 | RPS6 | PIN1 | HSF1 | MDM2 | BECN1 | DAPK1 | CAMKK2 | DAPK1 | Stx1a | MCM3 | MYL12B | Myl12b | RPL13A | GRIN2B | MYL12A | MYL9 | CDKN1A | STX1A | | |
| DAPK2 | Death-associated protein kinase 2 | Q9UIK4 | DAPK2 | MYL9 | DAPK1 | STX1A | CAMKK2 | |
| DAPK3 | Death-associated protein kinase 3 | O43293 | MYL9 | RPL13A | MYL12B | DAPK3 | TP53 | MDM2 | Myl9 | PPP1R12A | PPP1R14A | Myl9 | Dapk3 | CDKN1A | HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J | PPP1R12A | BECN1 | PPP1R12A | STAT3 | MYL9 | DAPK1 | STX1A | CAMKK2 | PPP1R12A | |
Substrates known in this pathway:
| Name | Protein Names | EntryName | Phosphorylated by CaM kinases |
|---|---|---|---|
| AKT1 | RAC-alpha serine/threonine-protein kinase | P31749 | MAPKAPK2 | SIK2 | PRKD1 | CAMKK2 | |
| BAD | Bcl2-associated agonist of cell death | Q92934 | RPS6KA3 | PRKD1 | RPS6KA2 | RPS6KA1 | PIM3 | PIM1 | CAMK2G | PIM2 | CHEK1 | |
| BCL2L1 | Bcl-2-like protein 1 | Q07817 | MAPKAPK2 | |
| CDKN1A | Cyclin-dependent kinase inhibitor 1 | P38936 | PIM2 | PIM1 | Stk11 | DAPK3 | NUAK1 | DAPK1 | |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B | P46527 | RPS6KA3 | PRKAA1 | CAMK1 | PIM1 | CAMK2A | RPS6KA2 | RPS6KA1 | PIM3 | PIM2 | |
| CREBBP | CREB-binding protein | Q92793 | CAMK4 | |
| CTNNB1 | Catenin beta-1 | P35222 | PRKD1 | CAMK2A | PRKAA2 | |
| DAPK1 | Death-associated protein kinase 1 | P53355 | RPS6KA3 | DAPK1 | RPS6KA2 | RPS6KA1 | DAPK3 | DAPK2 | STK17B | STK17A | |
| DAPK2 | Death-associated protein kinase 2 | Q9UIK4 | DAPK2 | |
| DAPK3 | Death-associated protein kinase 3 | O43293 | DAPK1 | DAPK3 | |
| E2F1 | Transcription factor E2F1 | Q01094 | CHEK2 | MAPKAPK2 | |
| E2F3 | Transcription factor E2F3 | O00716 | CHEK1 | CHEK2 | |
| EGFR | Epidermal growth factor receptor | P00533 | PRKD1 | CAMK2A | PRKAA1 | |
| EP300 | Histone acetyltransferase p300 | Q09472 | CAMK1 | Camk4 | PRKAA1 | Prkaa2 | CAMK4 | CAMK1D | CAMK1G | |
| ERBB2 | Receptor tyrosine-protein kinase erbB-2 | P04626 | CAMK2A | PRKAA1 | |
| ETS1 | Protein C-ets-1 | P14921 | CAMK2A | |
| FOS | Proto-oncogene c-Fos | P01100 | RPS6KA2 | RPS6KA1 | |
| GSK3B | Glycogen synthase kinase-3 beta | P49841 | RPS6KA3 | RPS6KA1 | PRKD3 | STK11 | CAMK2B | |
| HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | PNCK | |
| HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | PNCK | |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | O14920 | PRKAA2 | |
| ITGB1 | Integrin beta-1 | P05556 | CAMK2A | |
| JUN | Transcription factor AP-1 | P05412 | PRKD1 | |
| MDM2 | E3 ubiquitin-protein ligase Mdm2 | Q00987 | MAPKAPK2 | PIM1 | DAPK1 | DAPK3 | RPS6KA1 | PIM2 | |
| MITF | Microphthalmia-associated transcription factor | O75030 | |
| NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEK1 | |
| NFKBIA | NF-kappa-B inhibitor alpha | P25963 | RPS6KA3 | RPS6KA1 | |
| PLD1 | Phospholipase D1 | Q13393 | PRKAA2 | |
| PML | Protein PML | P29590 | CHEK2 | |
| PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | P60484 | STK11 | |
| RB1 | Retinoblastoma-associated protein | P06400 | CHEK1 | CHEK2 | |
| RELA | Transcription factor p65 | Q04206 | PIM1 | CAMK2G | RPS6KA4 | RPS6KA5 | CAMK4 | CHEK1 | |
| SKP2 | S-phase kinase-associated protein 2 | Q13309 | Pim1 | PIM1 | |
| SMAD2 | Mothers against decapentaplegic homolog 2 | Q15796 | Melk | CAMK2A | MELK | |
| SMAD4 | Mothers against decapentaplegic homolog 4 | Q13485 | Melk | STK11 | MELK | |
| STAT3 | Signal transducer and activator of transcription 3 | P40763 | RPS6KA3 | CAMK2G | Dapk3 | DAPK3 | |
| TP53 | Cellular tumor antigen p53 | P04637 | DAPK1 | MAPKAPK2 | STK11 | NUAK1 | MAPKAPK5 | STK17A | CHEK1 | DAPK3 | CHEK2 | PRKAA1 | SIK1 | MELK | PRKAA2 | |
| VHL | von Hippel-Lindau disease tumor suppressor | P40337 | CHEK2 | |