| Gene |
DCX
|
| Protein Name |
DCX_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) |
| Protein Family |
N/A |
| NCBI Gene ID |
1641
|
| UniProt ID |
O43602
|
| Enzyme Class |
- |
| Molecular Weight |
40574 |
| Protein Length |
365 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. |
| Gene Ontology |
GO:0001764; GO:0005829; GO:0005856; GO:0005874; GO:0005875; GO:0005930; GO:0007399; GO:0007417; GO:0008017; GO:0019901; GO:0035082; GO:0035556; GO:0042461; GO:0043005; GO:0060041 |
