CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

MARK4

Synonyms

KIAA1860 MARKL1

Protein Name

MAP/microtubule affinity-regulating kinase 4

UniProt ID

Q96L34

Ensembl Gene ID

9606.ENSP00000262891

NCBI Gene ID

57787

Molecular Weight

82,520

Protein Length

752

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 5es1)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm Cell projection, dendrite Note=Localized at the tips of neurite-like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus.

Function

Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).

Gene Ontology

GO:0000226; GO:0000930; GO:0001578; GO:0004674; GO:0005524; GO:0005737; GO:0005813; GO:0005815; GO:0005829; GO:0006468; GO:0007049; GO:0007399; GO:0008017; GO:0015630; GO:0030010; GO:0030425; GO:0030496; GO:0035556; GO:0036064; GO:0043005; GO:0043015; GO:0043068; GO:0043130; GO:0044782; GO:0045724; GO:0046605; GO:0050321; GO:0051301; GO:0097711; GO:1904781

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Crtc2 * (Q3U182)	Mus musculus	S171	SALNRTSSDSALHTS	-	0.6661	TP	likely	experimental	73 \|	20551288	-	-
Crtc2 * (Q3U182)	Mus musculus	S275	PAMNTGGSLPDLTNL	-	0.662	TP	likely	experimental	73 \|	20551288	-	-
Crtc2 * (Q3U182)	Mus musculus	S307	PSLSGGNSTTNLTHT	-	0.7163	TP	likely	experimental	73 \|	20551288	-	-
Rptor (Q8K4Q0)	Mus musculus	S792	DKMRRVSSYSALNSL	-	0.3149	TP	certain	experimental	72 \| 73 \| 147 \| 55 \| 9 \|	23184942	-	-
MAPT (P10636)	Homo sapiens	S579	NVKSKIGSTENLKHQ	0.79	0.8198	-	-	-	-	-	-	-
CRTC2 (Q53ET0)	Homo sapiens	S171	SALNRTSSDSALHTS	0.886	0.662	-	-	-	-	-	-	-
CRTC2 (Q53ET0)	Homo sapiens	S274	PAMNTGGSLPDLTNL	0.739	0.6712	-	-	-	-	-	-	-
CRTC2 (Q53ET0)	Homo sapiens	S306	PSLSGGNSTSNLTHT	0.885	0.7547	-	-	-	-	-	-	-
N/A (B7Z3S8)	Homo sapiens	S792	DKMRRASSYSSLNSL	-	0.2575	-	-	-	-	-	-	-
MAP4 (P27816)	Homo sapiens	S1073	KAQAKVGSLDNVGHL	0.692	0.5854	-	-	-	-	-	-	-
MAP4 (P27816)	Homo sapiens	S941	NVRSKVGSTENIKHQ	0.766	0.8162	-	-	-	-	-	-	-
HDAC7 (Q8WUI4)	Homo sapiens	S155	FPLRKTVSEPNLKLR	0.972	0.6322	-	-	-	-	-	-	-
DCX (O43602)	Homo sapiens	S47	TRTLQALSNEKKAKK	0.5	0.268	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found