CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

MARK3

Synonyms

CTAK1 EMK2

Protein Name

MAP/microtubule affinity-regulating kinase 3

UniProt ID

P27448

Ensembl Gene ID

9606.ENSP00000411397

NCBI Gene ID

4140

Molecular Weight

84,429

Protein Length

753

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 3fe3)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cell membrane Peripheral membrane protein Cell projection, dendrite Cytoplasm

Function

Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).

Gene Ontology

GO:0000165; GO:0000226; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006468; GO:0018105; GO:0030010; GO:0030425; GO:0032092; GO:0035331; GO:0035556; GO:0036289; GO:0050321; GO:0070062

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CDC25C (P30307)	Homo sapiens	S216	SGLYRSPSMPENLNR	0.868	0.6227	TP	certain	experimental	72 \| 9 \| 137 \| 135 \| 55 \| 73 \| 23 \|	9543386	-	-
PKP2 (Q99959)	Homo sapiens	S82	GNLHRTSSVPEYVYN	0.872	0.4369	TP	certain	experimental	72 \| 137 \| 135 \| 9 \|	12941695	-	-
PPP1R2 * (P41236)	Homo sapiens	S72	LMKIDEPSTPYHSMM	0.725	0.6531	U	likely	experimental	31 \| 72 \|	25028520	-	-
PTPN3 (P26045)	Homo sapiens	S359	PAMRRSLSVEHLETK	0.993	0.4149	TP	certain	experimental	62 \| 135 \| 72 \|	9341175	-	-
KSR1 (Q8IVT5)	Homo sapiens	S406	TRLRRTESVPSDINN	0.7	0.6183	-	-	-	-	-	-	-
Crtc2 (Q3U182)	Mus musculus	S275	PAMNTGGSLPDLTNL	-	0.662	-	-	-	-	-	-	In vitro
FEZ1 (Q99689)	Homo sapiens	S58	SEIISFKSMEDLVNE	0.828	0.4051	-	-	-	-	-	-	in-vitro and in-vivo
ARHGEF2 (Q92974)	Homo sapiens	S151	LSLAKSVSTTNIAGH	0.861	0.3529	-	-	-	-	-	-	in-vitro and in-vivo
MARK3 (P27448-3)	Homo sapiens	S598	TPLSQTRSRGSTNLF	-	-	-	-	-	-	-	-	-
MARK3 (P27448-3)	Homo sapiens	S601	SQTRSRGSTNLFSKL	-	-	-	-	-	-	-	-	-
MARK3 (P27448-3)	Homo sapiens	S606	RGSTNLFSKLTSKLT	-	-	-	-	-	-	-	-	-
HDAC7 (Q8WUI4)	Homo sapiens	S155	FPLRKTVSEPNLKLR	0.972	0.6322	-	-	-	-	-	-	-
CRTC2 (Q53ET0)	Homo sapiens	S274	PAMNTGGSLPDLTNL	0.739	0.6712	-	-	-	-	-	-	-
MAP4 (P27816)	Homo sapiens	S1073	KAQAKVGSLDNVGHL	0.692	0.5854	-	-	-	-	-	-	-
MAP4 (P27816)	Homo sapiens	S941	NVRSKVGSTENIKHQ	0.766	0.8162	-	-	-	-	-	-	-
DCX (O43602)	Homo sapiens	S47	TRTLQALSNEKKAKK	0.5	0.268	-	-	-	-	-	-	-
MARK3 (P27448-3)	Homo sapiens	T602	QTRSRGSTNLFSKLT	-	-	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found