| Gene |
ADCY3
|
| Protein Name |
ADCY3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3) |
| Protein Family |
Adenylyl cyclase class-4/guanylyl cyclase family |
| NCBI Gene ID |
109
|
| UniProt ID |
O60266
|
| Enzyme Class |
4.6.1.1 |
| Molecular Weight |
128960 |
| Protein Length |
1144 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP = 3' |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. |
| Gene Ontology |
GO:0003091; GO:0004016; GO:0005516; GO:0005524; GO:0005737; GO:0005794; GO:0005886; GO:0005887; GO:0005929; GO:0006171; GO:0007165; GO:0007186; GO:0007189; GO:0007193; GO:0007338; GO:0007340; GO:0007608; GO:0008355; GO:0016020; GO:0016021; GO:0030317; GO:0046872; GO:0071377; GO:1904322 |
