| Gene |
TFAP2A
|
| Protein Name |
AP2A_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) |
| Protein Family |
AP-2 family |
| NCBI Gene ID |
7020
|
| UniProt ID |
P05549
|
| Enzyme Class |
- |
| Molecular Weight |
48062 |
| Protein Length |
437 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. |
| Gene Ontology |
GO:0000122; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0000982; GO:0000987; GO:0001077; GO:0001078; GO:0001822; GO:0003404; GO:0003409; GO:0003682; GO:0003713; GO:0005634; GO:0005654; GO:0005794; GO:0005813; GO:0005829; GO:0006357; GO:0007605; GO:0008285; GO:0010628; GO:0010842; GO:0010944; GO:0021559; GO:0021623; GO:0030501; GO:0035115; GO:0042472; GO:0042803; GO:0043066; GO:0043231; GO:0043525; GO:0043565; GO:0044212; GO:0045595; GO:0045892; GO:0045893; GO:0045944; GO:0046983; GO:0048701; GO:0060021; GO:0060349; GO:0061029; GO:0070172; GO:0071281; GO:2000378 |
