CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	TH
Protein Name	TY3H_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH)
Protein Family	Biopterin-dependent aromatic amino acid hydroxylase family
NCBI Gene ID	7054
UniProt ID	P07101
Enzyme Class	1.14.16.2
Molecular Weight	58600
Protein Length	528
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin.
Localization	N/A
Function (UniProt annotation)	Plays an important role in the physiology of adrenergic neurons.
Gene Ontology	GO:0001666; GO:0001963; GO:0001975; GO:0003007; GO:0004511; GO:0005634; GO:0005737; GO:0005739; GO:0005790; GO:0005829; GO:0006585; GO:0006631; GO:0006665; GO:0007507; GO:0007601; GO:0007605; GO:0007612; GO:0007613; GO:0007617; GO:0007626; GO:0008016; GO:0008021; GO:0008198; GO:0008199; GO:0009414; GO:0009416; GO:0009635; GO:0009651; GO:0009653; GO:0009887; GO:0009898; GO:0010043; GO:0010259; GO:0014823; GO:0015842; GO:0016137; GO:0016597; GO:0018963; GO:0019825; GO:0019899; GO:0019904; GO:0021987; GO:0030425; GO:0031410; GO:0031667; GO:0032355; GO:0032496; GO:0033076; GO:0033162; GO:0034617; GO:0035176; GO:0035240; GO:0035900; GO:0035902; GO:0042136; GO:0042214; GO:0042416; GO:0042418; GO:0042421; GO:0042423; GO:0042462; GO:0042745; GO:0042755; GO:0043005; GO:0043195; GO:0043204; GO:0043434; GO:0043473; GO:0045471; GO:0045472; GO:0046684; GO:0048596; GO:0051412; GO:0051602; GO:0052314; GO:0071287; GO:0071312; GO:0071316; GO:0071333; GO:0071363

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK2 (P49137)	Homo sapiens	S19	KGFRRAVSELDAKQA	0.455	N/A	TP	certain	experimental	73 \| 107 \|	7901013	-	In vitro
MAPKAPK2 (P49137)	Homo sapiens	S40	GQGAPGPSLTGSPWP	0.09	N/A	TP	certain	experimental	73 \| 107 \|	7901013	-	In vitro
MAPKAPK5* (Q8IW41)	Homo sapiens	S19	KGFRRAVSELDAKQA	N/A	N/A	TP	certain	experimental	30 \| 135 \| 72 \|	12421349	-	-
MAPKAPK5* (Q8IW41)	Homo sapiens	S40	RFIGRRQSLIEDARK	N/A	N/A	U	likely	experimental	30 \| 135 \| 72 \|	12421349	-	-
MAPKAPK5* (Q8IW41)	Homo sapiens	S404	GELLHCLSEEPEIRA	N/A	N/A	U	likely	experimental	30 \| 135 \| 72 \|	12421349	-	-
RPS6KA5 (O75582)	Homo sapiens	S40	RFIGRRQSLIEDARK	N/A	N/A	-	-	-	-	-	-	In vitro
MAPKAPK2 (P49137)	Homo sapiens	S404	GELLHCLSEEPEIRA	N/A	N/A	-	-	-	-	-	-	In vitro
RPS6KA3 (P51812)	Homo sapiens	S40	RFIGRRQSLIEDARK	N/A	N/A	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S40	RFIGRRQSLIEDARK	N/A	N/A	-	-	-	-	-	-	In vitro

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found