| Gene |
RARA
|
| Protein Name |
RARA_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) |
| Protein Family |
Nuclear hormone receptor family |
| NCBI Gene ID |
5914
|
| UniProt ID |
P10276
|
| Enzyme Class |
- |
| Molecular Weight |
50771 |
| Protein Length |
462 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. Cytoplasm. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation. |
| Function (UniProt annotation) |
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). |
| Gene Ontology |
GO:0000122; GO:0000790; GO:0000900; GO:0000976; GO:0000977; GO:0000981; GO:0001657; GO:0001843; GO:0001889; GO:0001972; GO:0002068; GO:0003148; GO:0003417; GO:0003700; GO:0003707; GO:0003708; GO:0003713; GO:0003714; GO:0005102; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006367; GO:0006468; GO:0007165; GO:0007275; GO:0007281; GO:0007283; GO:0007565; GO:0008134; GO:0008144; GO:0008270; GO:0008284; GO:0008285; GO:0009755; GO:0009986; GO:0015629; GO:0019899; GO:0019904; GO:0021766; GO:0030154; GO:0030374; GO:0030425; GO:0030850; GO:0030853; GO:0031076; GO:0031490; GO:0031641; GO:0032355; GO:0032526; GO:0032689; GO:0032720; GO:0032736; GO:0032753; GO:0032754; GO:0033189; GO:0033993; GO:0034097; GO:0035264; GO:0038023; GO:0042826; GO:0043066; GO:0043277; GO:0043422; GO:0044323; GO:0045471; GO:0045630; GO:0045666; GO:0045787; GO:0045892; GO:0045893; GO:0045944; GO:0046982; GO:0048027; GO:0048167; GO:0048384; GO:0048471; GO:0048732; GO:0051018; GO:0051099; GO:0051393; GO:0055012; GO:0060010; GO:0060173; GO:0060324; GO:0060349; GO:0060429; GO:0060534; GO:0060591; GO:0061037; GO:0071222; GO:0071300; GO:0071391; GO:0090575 |
