CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Creb1
Protein Name	CREB1_RAT
Organism	Rattus norvegicus (Rat)
Alternative name(s)	Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1)
Protein Family	BZIP family
NCBI Gene ID	81646
UniProt ID	P15337
Enzyme Class	-
Molecular Weight	36633
Protein Length	341
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus.
Function (UniProt annotation)	Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity).
Gene Ontology	GO:0000785; GO:0000790; GO:0000980; GO:0001102; GO:0001225; GO:0001228; GO:0001666; GO:0003690; GO:0003700; GO:0003705; GO:0005634; GO:0005654; GO:0005667; GO:0005719; GO:0005739; GO:0005759; GO:0006366; GO:0006468; GO:0007179; GO:0007409; GO:0007568; GO:0007595; GO:0007613; GO:0007623; GO:0008134; GO:0008361; GO:0008542; GO:0010629; GO:0010944; GO:0014823; GO:0021983; GO:0030424; GO:0030544; GO:0032916; GO:0033363; GO:0033762; GO:0034670; GO:0035035; GO:0035094; GO:0035497; GO:0035729; GO:0036120; GO:0040018; GO:0042493; GO:0042752; GO:0042802; GO:0042981; GO:0043065; GO:0043565; GO:0044212; GO:0045600; GO:0045672; GO:0045893; GO:0045899; GO:0045944; GO:0046887; GO:0046889; GO:0048145; GO:0050821; GO:0055025; GO:0060251; GO:0060430; GO:0060509; GO:0071294; GO:0071300; GO:0071398; GO:0071560; GO:1900273; GO:1901215; GO:1902065; GO:1990090; GO:1990314; GO:1990589; GO:1990763; GO:1990830

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA3 (P51812)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	TP	certain	-	72 \| 55 \| 205 \|	8688081	-	In vivo
CAMK4 (Q16566)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	certain	experimental	72 \| 73 \| 107 \| 9 \|	7958915	-	In vivo
RPS6KA5 (O75582)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	In vitro
MAPKAPK2 (P49137)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S133	EILSRRPSYRKILND	N/A	0.5055	-	-	-	-	-	-	In vitro and in vivo
CAMK2A (Q9UQM7)	Homo sapiens	S142	RKILNDLSSDAPGVP	N/A	0.5807	-	-	-	-	-	-	In vitro

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
rno04380	Osteoclast differentiation
rno04612	Antigen processing and presentation
rno04725	Cholinergic synapse
rno04916	Melanogenesis
rno04962	Vasopressin-regulated water reabsorption
rno05016	Huntington's disease
rno05152	Tuberculosis
rno05215	Prostate cancer

No NCI Nature pathways found