| Gene |
ATP2A2
|
| Protein Name |
AT2A2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 3.6.3.8) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) |
| Protein Family |
Cation transport ATPase (P-type) (TC 3.A.3) family |
| NCBI Gene ID |
488
|
| UniProt ID |
P16615
|
| Enzyme Class |
3.6.3.8 |
| Molecular Weight |
114757 |
| Protein Length |
1042 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). |
| Localization |
Endoplasmic reticulum membrane |
| Function (UniProt annotation) |
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity). |
| Gene Ontology |
GO:0002026; GO:0003009; GO:0005388; GO:0005509; GO:0005524; GO:0005654; GO:0005783; GO:0005789; GO:0005887; GO:0006874; GO:0006984; GO:0006996; GO:0007155; GO:0008022; GO:0008544; GO:0008553; GO:0010460; GO:0010882; GO:0012506; GO:0014801; GO:0014883; GO:0014898; GO:0016020; GO:0016529; GO:0019899; GO:0031095; GO:0031234; GO:0031775; GO:0032469; GO:0032470; GO:0032496; GO:0032991; GO:0033017; GO:0033292; GO:0034220; GO:0034599; GO:0034605; GO:0034976; GO:0044548; GO:0045822; GO:0048471; GO:0055119; GO:0061831; GO:0070296; GO:0070588; GO:0086036; GO:0086039; GO:0090534; GO:0097470; GO:0098909; GO:0120025; GO:1903233; GO:1903515; GO:1903779; GO:1990036 |
