| Gene |
ATF1
|
| Protein Name |
ATF1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36) |
| Protein Family |
BZIP family |
| NCBI Gene ID |
466
|
| UniProt ID |
P18846
|
| Enzyme Class |
- |
| Molecular Weight |
29233 |
| Protein Length |
271 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. |
| Gene Ontology |
GO:0000977; GO:0000981; GO:0001228; GO:0003700; GO:0003705; GO:0005634; GO:0005654; GO:0005667; GO:0010976; GO:0014070; GO:0032025; GO:0034622; GO:0042802; GO:0044877; GO:0045740; GO:0045944; GO:0046982; GO:1990590 |
