CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	XRCC1
Protein Name	XRCC1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)
Protein Family	N/A
NCBI Gene ID	7515
UniProt ID	P18887
Enzyme Class	-
Molecular Weight	69477
Protein Length	633
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus
Function (UniProt annotation)	Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.
Gene Ontology	GO:0000012; GO:0000724; GO:0000784; GO:0000790; GO:0001666; GO:0003909; GO:0005634; GO:0005654; GO:0005730; GO:0006283; GO:0006284; GO:0006288; GO:0006297; GO:0006303; GO:0010033; GO:0010836; GO:0019899; GO:0021587; GO:0021766; GO:0032356; GO:0033194; GO:0042493; GO:0050882; GO:0061819; GO:0070522; GO:1903518; GO:1904877; GO:1905765; GO:1990414; GO:1990599

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK2 (O96017)	Homo sapiens	S184	EEDESANSLRPGALF	0.514	0.5707	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S210	ASDPAGPSYAAATLQ	0.903	0.7331	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	T284	APTRTPATAPVPARA	0.433	0.8421	-	-	-	-	-	-	In vitro and in vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa03410	Base excision repair

NCI Nature PID Pathways

Pathway ID	Pathway Name
foxm1pathway	FOXM1 transcription factor network