CaM Kinases known in this pathway:
| Name | Synonyms | EntryName | Phosphorylate Substrates |
|---|---|---|---|
| CHEK2 | Serine/threonine-protein kinase Chk2 | O96017 | E2F3 | E2F3 | MDM4 | REV3L | CHEK2 | MBP | TP53 | RB1 | MAPT | HIST1H1C | XRCC1 | PML | CDC25A | CDC25C | BRCA1 | VHL | | E2F1 | FOXM1 | TRIM28 | ELAVL1 | LATS2 | AATF | TTK | Cds1 | SIAH2 | BAIAP2L1 | PSME3 | CDK11B | BLM | BDNF | MBP | CHEK2 | CHEK2 | PML | FOXM1 | CDK11A | CHEK2 | BRCA2 | MBP | |
Substrates known in this pathway:
| Name | Protein Names | EntryName | Phosphorylated by CaM kinases |
|---|---|---|---|
| AURKB | Aurora kinase B | Q96GD4 | CHEK1 | |
| CDC25B | M-phase inducer phosphatase 2 | P30305 | MELK | MAPKAPK2 | BRSK1 | CHEK1 | RPS6KA1 | |
| CHEK2 | Serine/threonine-protein kinase Chk2 | O96017 | CHEK2 | |
| CREBBP | CREB-binding protein | Q92793 | CAMK4 | |
| EP300 | Histone acetyltransferase p300 | Q09472 | CAMK1 | Camk4 | PRKAA1 | Prkaa2 | CAMK4 | CAMK1D | CAMK1G | |
| ESR1 | Estrogen receptor | P03372 | RPS6KA3 | RPS6KA1 | |
| FOS | Proto-oncogene c-Fos | P01100 | RPS6KA2 | RPS6KA1 | |
| FOXM1 | Forkhead box protein M1 | Q08050 | CHEK2 | |
| GSK3A | Glycogen synthase kinase-3 alpha | P49840 | RPS6KA3 | PRKD3 | |
| PLK1 | Serine/threonine-protein kinase PLK1 | P53350 | MAPKAPK2 | |
| RB1 | Retinoblastoma-associated protein | P06400 | CHEK1 | CHEK2 | |
| SKP2 | S-phase kinase-associated protein 2 | Q13309 | Pim1 | PIM1 | |
| XRCC1 | DNA repair protein XRCC1 | P18887 | CHEK2 | |
| CDC25B | M-phase inducer phosphatase 2 | P30305 | MELK | MAPKAPK2 | BRSK1 | CHEK1 | RPS6KA1 | |